Publications

2025

• Kim, N., Kim, S., Park, S., and Kim, E.-K* (2025) Adenosine transmission from hypothalamic tanycytes to AGRP/NPY neurons regulates energy homeostasis. Experimental & Molecular Medicine. [link](한빛사)

2024

• Park, S., and Kim, E.-K* (2024) Machine Learning-Based Plasma Metabolomics in Liraglutide-Treated Type 2 Diabetes Mellitus Patients and Diet-Induced Obese Mice. Metabolites 14(9) 483. [link]

2023​

• Park, S., Oh, S., Kim, N. and Kim, E.-K.* (2023) HMBA ameliorates obesity by MYH9- and ACTG1-dependent regulation of hypothalamic neuropeptides. EMBO Molecular Medicine (15)12 e18024. [link] (한빛사)

• Jung, Y.-E., Lee, K.W., Cho, J.H., Bae, D.-W., Jeong, B.-G., Jung, Y.-J., Park, S.-B., An, Y.J., Kim, K., Lee, G.S., Kang, L.-W., Moon, J.H., Lee, J.-H., Kim, E.-K., Yim, H.-S. and Cha, S.-S. (2023) Heating-mediated purification of active FGF21 and structural- based design of its variant with enhanced potency. Scientific Reports (13):1. [link]

​2022

• Park, S., Oh, S. and Kim, E.-K.* (2022) Glucagon-like peptide-1 analog liraglutide leads to multiple metabolic alterations in diet-induced obese mice. Journal of Biological Chemistry 298(12):102682. [link]

• Cho, J.H., Kim, K., Cho, H.C., Lee, J. and Kim, E.-K.* (2022) Silencing of hypothalamic FGF11 prevents diet-induced obesity. Molecular Brain 15:75. [link]

• Nam, H., Lee, Y., Kim, B., Lee, J.-W., Hwang, S., An, H.-K., Chung, K.M., Park, Y., Hong, J., Kim, K., Kim, E.-K.*, Choe, H.K. and Yu, S.-W. (2022) Presenilin2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBa. Nature Communications 13:1972. [link] (한빛사)

2021

• Jeon, Y., Lim, Y., Yeom, J. and Kim, E.-K.* (2021) Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory.  Molecular Brain 14 (1):153. [link]

• Lim, Y., Kim, S. and  Kim, E.-K.* (2021) Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells.  Molecular Brain 14(1):65. [link]

• Chung, I., Kim, S.A., Kim, S., Lee, J.O., Park, Y., Lee, J., Lee, J.Y., Seo, I., Lee, H.J., Han, H.A., Kang, M.J., Lim, E., Kim, S.J., Chung, J.H., Kim, E.-K., Kim, H.S. and Shin, M.-J. (2021) Biglycan reduces body weight by regulating food intake in mice and improves glucose metabolism through AMPK/AKT dual pathways in skeletal muscle. FASEB J 35(8):e21794. [link]

• Choi, Y., Song, M.-J., Jung, W.-J., Jeong, H., Park, S., Yang, B., Lee, E.-C., Joo, J.-S., Choi, D., Koo, S.-H., Kim, E.-K., Nam, K.T., and Kim, H.-P. (2021) Liver-specific deletion of mouse CTCF leads to hepatic steatosis via augmented PPARr signaling. Cellular and Molecular Gastroenterology and Hepatology 12(5): 1761-1787. [link]

• Ryu, H.Y., Kim, E., Jeong, H., Lee, J.-W., Nam, H., Ha, S., An, H.K., Park, H.H., Jung, S., Chung, K.M., Kim, J., Lee, B.-H., Cheong, H., Kim, E.-K.* and Yu, S.-W. (2021) GSK3B induces autophagy by phosphorylating and stabilizing ULK1. Experimental & Molecular Medicine 53(3): 369-383. [link]

• Klionsky et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 17(1):1-382. [link]

2020

• Jo, C., Park, S., Oh, S., Choi, J.,, Youn, H.-D., Kim, E-K.* and Cho, E.-J. (2020) Histone acylation marks respond to metabolic perturbations and enable cellular adaptation. Experimental & Molecular Medicine 52(12):2005-2019.  [link]

• Lee, J., Kim, K., Cho, J.H., Bae, J.Y., O'Leary, T.P., Johnson, J.D., Bae, Y.C. and Kim, E.-K.* (2020) Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production. JCI Insight 5(16):e135412. [link]

• Kwak, S.Y., Chung, I., Kang, J., Perakakis, N., Yoo, E.H., Lee, J., Jung, H.T., Mun, B.R., Choi, W.S., Kim, O.Y., Kim, S., Kim, E.-K., Oh, H., Mantzoros, C.S., Chung, J.H., Kim, H.S.,  and Shin, M.J. (2020) Sex specific effect of ATPase inhibitory factor 1 on body weight: studies in high fat diet induced obese mice and genetic association studies in humans. Metabolism Clinical & Experimental 105:154171. [link]

• Kim, S., Kim, N., Park, S., Lee, J.-W., Jeon, Y., Lee, J., Yoo, S.-J., Moon, C., Yu, S.-W. and Kim, E.-K.* (2020) Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance. Autophagy 16(7):1200-1220. [link] (한빛사)

• Jung, S., Choe, S., Woo, H., Jeong, H., An, H.-K., Moon, H., Ryu, H.Y., Yeo, B.K., Lee, Y.W., Choi, H., Mun, J.Y., Sun, W., Choe, H.K., Kim, E.-K.* and Yu, S.-W. (2020) Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits. Autophagy 16(3):512-530. [link] (한빛사)

2019

• Park, S., Oh, T.S., Kim, S. and Kim, E.-K.* (2019) Palmitate-induced autophagy liberates monounsaturated fatty acids and increases Agrp expression in hypothalamic cells. Anim Cells Syst 23(6):384-391. [link]

• Lee, J.-W., Nam, H., Kim., L.E., Jeon, Y., Min, H., Ha, S., Lee, Y., Kim, S.-Y., Lee, S.J., Kim, E.-K.* and Yu, S.-W. (2019) Toll-like receptor 4 activation suppresses autophagy through inhibition of FoxO3 and impairs phagocytic capacity of microglia. Autophagy 15(5):753-770. [link] (한빛사)

2017

• Ha, S., Jeong, S.-H., Yi, K., Chung, K.M., Hong, C.J., Kim, S.W., Kim, E.-K. and Yu, S.-W. (2017) Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells. Journal of Biological Chemistry 292:13795-13808. [link]

2016

• Oh, T.S., Cho, H., Cho, J.H., Yu, S.-W. and Kim, E.-K.* (2016) Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression. Autophagy 12(11):2009-2025. [link] (한빛사)

• Oh, T.S., Jeon, Y., Kim, S. and Kim, E.-K.* (2016) Hypothalamic AMP-activated Protein Kinase as a Regulator of Food Intake and Energy Balance. CNS and neurological disorder-Drug Targets 15(8):896-909. [link]

• Lee, J.-W., Kim, L.E., Shim, H.-J., Kim, E.-K., Hwang, W.C., Min, D.S. and Yu, S.-W. (2016) A translocator protein 18 kDa ligand, Ro5-4864 inhibits ATP-induced NLRP3 inflammasome activation. BBRC 474(3):587-593. [link]

• Ryu, J.R., Hong, C.J., Kim, J.Y., Kim, E.-K., Sun, W. and Yu, S.W. (2016) Control of adult neurogenesis by programmed cell death in the mammalian brain. Molecular Brain 9(43). [link]

• Yeo, B.K., Hong, J., Chung, K.M., Woo, H., Kim, K., Jung, S., Kim, E.-K.* and Yu, S.-W. (2016) Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawl. Molecular Brain 9(31). [link]

• Lim, Y., Cho, H. and Kim, E.-K.* (2016) Brain metabolism as a modulator of autophagy in neurodegeneration. Brain Research 1649(pt B):158-165. [link]

• Lee, J., Kim, K., Yu, S.-W. and Kim, E.-K.* (2016) Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/beta-catenin signaling in the hypothalamus. Molecular Brain 9(24). [link]

• Shim, H., Park, S., Lee, J.-W., Park, H.-J., Baek, S.-H., Kim, E.-K.* and Yu, S.-W. (2016) Extracts from Dendropanax morbifera leaves have modulatory effects on neuroinflammation in microglia. American Journal of Chinese Medicine 44(1): 119-32. [link]

• Jeon, Y., Aja, S., Ronnett, G.V. and Kim, E.-K.* (2016) d-chiro-inositol glycan reduces food intake by regulating hypothalamic neuropeptide expression via AKT-FoxO1 pathway. BBRC 470(4):818-823. [link]

2015

• Chung, K.M., Park, H., Jung, S., Ha, S., Yoo, S.J., Woo, H., Lee, H.J., Kim, S.W., Kim, E.-K., Moon, C. and Yu, S.-W. (2015). Calpain determines the propensity of adult hippocampal neural stem cells to autophagic cell death following insulin withdrawal. Stem cells 33(10):3052-64. [link]

• Park, S., Krishna Chaitanya, S. and Kim, E.-K.* (2015) A metabolomic approach to understanding the metabolic link between obesity and diabetes. Molecules and Cells 38(7):587-596. [link]

• Kim, S.Y., Yoo, S.J., Ronnett, G.V., Kim, E.-K. and Moon, C. (2015) Odorant stimulation promotes survival of rodent olfactory receptor neurons via pi3k/akt activation and bcl-2 expression. Molecules and Cells 38(6). [link]

• Ha, S., Ryu, H.Y., Chung, K.M., Baek, S.H., Kim, E.-K.* and Yu, S.-W. (2015) Regulation of autophagic cell death by glycogen synthase kinase-3beta in adult hippocampal neural stem cells following insulin withdrawal. Molecular Brain 8(30). [link]

• Kim, S.Y., Mammen, A., Yoo, S.J., Cho, B., Kim, E.-K., Park, J.I., Moon, C. and Ronnett, G.V. (2015) Phosphoinositide and erk signaling pathways mediate activity-driven rodent olfactory sensory neuronal survival and stress mitigation. Journal of Neurochemistry 134:486-498. [link]

• Jung, M., Lee, J., Seo, H.-Y., Lim, J.S. and Kim, E.-K.* (2015) Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose. PloS one 10(1). [link]

2014

• McFadden, J.W., Aja, S., Li, Q., Bandaru, V.V., Kim, E.-K., Haughey, N.J., Kuhajda, F.P. and Ronnett, G.V. (2014) Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation. PLoS One 9, e115642. [link]

• Jung, H. -S, Lim, Y., and Kim E. -K.* (2014) Therapeutic Phytogenic Compounds for Obesity and Diabetes. International Journal of Molecular Sciences 15(11): 21505-21537. [link]

2013

• Lee, Y. and Kim, E.-K.* (2013) AMP-activated protein kinase as a key molecular link between metabolism and clockwork. Experimental & Molecular Medicine 45(7), e33. [link]

2012

• Zhu, J., Aja, S., Kim, E.-K., Park, M.-J., Ramamurthy, S., Jia, J., Hu, X., Geng, P. and Ronnett, G.V. (2012) Physiological Oxygen Level Is Critical for Modeling Neuronal Metabolism In Vitro. Jounral of neuroscience research 90: 422-434. [link]

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